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| Gregor Mendel |
Mendelian principles : Dominance, segregation, independent
assortment.
Concept of gene : Allele, multiple alleles, pseudoallele,
complementation tests
Extensions of Mendelian principles: Codominance, incomplete dominance, gene interactions,
pleiotropy, genomic imprinting, penetrance and expressivity, phenocopy, linkageand crossing over, sex linkage, sex limited and sex influenced characters.
Gene mapping methods : Linkage maps, tetrad analysis, mapping with molecular markers, mapping
by using somatic cell hybrids, development of mapping population in plants.
Extra chromosomal inheritance: Inheritance of Mitochondrial and chloroplast
genes, maternal inheritance.
Microbial genetics: Methods of genetic transfers transformation,conjugation, transduction
and sexduction, mapping genes by interrupted mating, fine structure analysis of
genes.
Human genetics : Pedigree analysis, lod score for linkage testing, karyotypes, genetic disorders.
Quantitative genetics : Polygenic inheritance, heritability and its measurements, QTL mapping.
Mutation : Types, causes and detection, mutant types – lethal, conditional,
biochemica loss of function, gain of function, germinal verses somatic mutants,
insertional mutagenesis.
Structural and numerical alterations of chromosomes : Deletion,
duplication, inversion, translocation, ploidy and their genetic implications.
Recombination : Homologous and non-homologous recombination including transposition.